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DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide SR4233, as a function of pHTOCHER, J. H; VIRK, N. S; EDWARDS, D. I et al.Biochemical pharmacology. 1990, Vol 40, Num 6, pp 1405-1410, issn 0006-2952, 6 p.Article

High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materialsWALTON, M. I; WORKMAN, P.Journal of chromatography. 1988, Vol 430, Num 2, pp 429-437, issn 0021-9673Article

Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditionsCAHILL, A; JENKINS, T. C; WHITE, I. N. H et al.Biochemical pharmacology. 1993, Vol 45, Num 2, pp 321-329, issn 0006-2952Article

Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditionsSILVA, J. M; O'BRIEN, P. J.British journal of cancer. 1993, Vol 68, Num 3, pp 484-491, issn 0007-0920Article

Targeting bioreductive drugs to tumours : is it necessary to manipulate blood flow ?BROWN, J. M.International journal of radiation biology (Print). 1991, Vol 60, Num 1-2, pp 231-236, issn 0955-3002Conference Paper

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agentCOSTA, A. K; BAKER, M. A; MARTIN BROWN, J et al.Cancer research (Baltimore). 1989, Vol 49, Num 4, pp 925-929, issn 0008-5472Article

Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxideLADEROUTE, K. R; RAUTH, A. M.Biochemical pharmacology. 1986, Vol 35, Num 19, pp 3417-3420, issn 0006-2952Article

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumorsBROWN, J. M; LEMMON, M. J.Cancer research (Baltimore). 1990, Vol 50, Num 24, pp 7745-7749, issn 0008-5472, 5 p.Article

Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin : a comparison with rates of reduction in microsomal systems from target organsWHITE, I. N. H; CAHILL, A; DAVIES, A et al.Archives of toxicology. 1992, Vol 66, Num 2, pp 100-106, issn 0340-5761Article

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liverWALTON, M. I; WOLF, C. R; WORKMAN, P et al.Biochemical pharmacology. 1992, Vol 44, Num 2, pp 251-259, issn 0006-2952Article

Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathingMINCHINTON, A. I; BROWN, J. M.British journal of cancer. 1992, Vol 66, Num 6, pp 1053-1058, issn 0007-0920Article

Aerobic radiosensitization by SR 4233 in vitro and in vivoZEMAN, E. M; LEMMON, M. J; BROWN, J. M et al.International journal of radiation oncology, biology, physics. 1990, Vol 18, Num 1, pp 125-132, issn 0360-3016Article

Tirapazamine (SR 4233) interrupts cell cycle progression and induces apoptosisLIN, P.-S; HO, K.-C; YANG, S.-J et al.Cancer letters. 1996, Vol 105, Num 2, pp 249-255, issn 0304-3835Article

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicityBAKER, M. A; ZEMAN, E. M; HIRST, V. K et al.Cancer research (Baltimore). 1988, Vol 48, Num 21, pp 5947-5952, issn 0008-5472Article

The hypoxic cytotoxin SR 4233 increases the effectiveness of radioimmunotherapy in mice with human non-Hodgkin's lymphoma xenograftsWILDER, R. B; MCGANN, J. K; SUTHERLAND, W. R et al.International journal of radiation oncology, biology, physics. 1994, Vol 28, Num 1, pp 119-126, issn 0360-3016Article

Enzymology of the reduction of the potent benzotriazidine-Di-N-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAd(P)H : (quinone acceptor) oxidoreductase (EC 1.699.2) purified from walker 256 rat tumor cellsRILEY, R. J; WORKMAN, P.Biochemical pharmacology. 1992, Vol 43, Num 2, pp 167-174, issn 0006-2952Article

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell linesCAHILL, A; WHITE, N. H.Carcinogenesis (New York. Print). 1990, Vol 11, Num 8, pp 1407-1411, issn 0143-3334, 5 p.Article

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiationKEOHANE, A; GODDEN, J; STRATFORD, I. J et al.British journal of cancer. 1990, Vol 61, Num 5, pp 722-726, issn 0007-0920Article

Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiationJINGLI WANG; BIEDERMANN, K. A; BROWN, J. M et al.Cancer research (Baltimore). 1992, Vol 52, Num 16, pp 4473-4477, issn 0008-5472Article

Bioreductive drugs and the selective induction of tumour hypoxiaBREMNER, J. C. M; STRATFORD, I. J; BOWLER, J et al.British journal of cancer. 1990, Vol 61, Num 5, pp 717-721, issn 0007-0920Article

NAD(P)H : quinone oxidoreductase₁(DT-diaphorase) expression in normal and tumor tissuesBELINSKY, M; JAISWAL, A. K.Cancer metastasis reviews. 1993, Vol 12, Num 2, pp 103-117, issn 0167-7659Article

Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells : enzymatic studiesWANG, J; BIEDERMANN, K. A; WOLF, C. R et al.British journal of cancer. 1993, Vol 67, Num 2, pp 321-325, issn 0007-0920Article

Interaction of the bioreductive drug SR 4233 and photodynamic therapy using photofrin in a mouse tumor modelBAAS, P; OPPELAAR, H; STAVENUITER, M et al.International journal of radiation oncology, biology, physics. 1993, Vol 27, Num 3, pp 665-670, issn 0360-3016Article

Enzymology of the reductive bioactivation of SR 4233 : a novel benzotriazine DI-N-oxide hypoxic cell cytotoxinWALTON, M. I; WORKMAN, P.Biochemical pharmacology. 1990, Vol 39, Num 11, pp 1735-1742, issn 0006-2952, 8 p.Article